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Publications

Scientific publications represent the heart of HEAL ITALIA‘s research.
Every paper tells the story of a discovery, an innovation, a step forward towards Precision Medicine accessible to all. The results are organised by Spoke, the eight thematic strands of the project: from the identification of biomarkers to innovative therapies, from early diagnosis to AI-supported clinical validation.

Validation in type 2 diabetes of a metabolomic signature of all-cause mortality

Massimiliano Copetti, Marco Giorgio Baroni, Raffaella Buzzetti, Maria Gisella Cavallo, Efiso Cossu, Paola D’Angelo, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Antonio...
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Cardiovascular Diseases | BMP signaling promotes heart regeneration via alleviation of replication stress

Mohan Dalvoy Vasudevarao, Denise Posadas Pena, Michaela Ihle, Chiara Bongiovanni, Pallab Maity, Simone Redaelli, Kathrin Happ, Dominik Geissler, Hossein Falah Mohammadi, Melanie Rall-Scharpf, Chi-Chung Wu, Arica Beisaw, Karin Scharffetter-Kochanek, Gabriele...
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BRCA1 foci test as a predictive biomarker of olaparib response in ovarian cancer patient-derived xenograft models

Federica Guffanti, Ilaria Mengoli, Maria Francesca Alvisi, Giulia Dellavedova, Raffaella Giavazzi, Robert Fruscio, Eliana Rulli, Giovanna Damia
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Dissecting human anatomy learning process through anatomical education with augmented reality: AEducAR 2.0, an updated interdisciplinary study

Irene Neri, Laura Cercenelli, Massimo Marcuccio, Simone Lodi, Foteini-Dionysia Koufi, Antonietta Fazio, Maria Vittoria Marvi, Emanuela Marcelli, Anna Maria Billi, Alessandra Ruggeri …
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Oropharyngeal microbial ecosystem perturbations influence the risk for acute respiratory infections in common variable immunodeficiency

Federica Pulvirenti, Maria Giufrè, Tancredi M. Pentimalli, Romina Camilli, Cinzia Milito, Annalisa Villa, Eleonora Sculco, Marina Cerquetti, Annalisa Pantosti, Isabella Quinti
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Cardiovascular diseases | Influence of quitting smoking on diabetes-related complications: A scoping review with a systematic search strategy

Magdalena Walicka, Arkadiusz Krysiński, Giusy Rita Maria La Rosa, Ang Sun, Davide Campagna, Agostino Di Ciaula, Tabinda Dugal, Andre Kengne, Phuong Le Dinh, Anoop Misra, Riccardo Polosa, Syed Abbas Raza,...
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ARID1A Mutations in Gastric Cancer: A Review with Focus on Clinicopathological Features, Molecular Background and Diagnostic Interpretation

Giuseppe Angelico, Giulio Attanasio, Lorenzo Colarossi, Cristina Colarossi, Matteo Montalbano, Eleonora Aiello, Federica Di Vendra, Marzia Mare, Nicolas Orsi, Lorenzo Memeo
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A Key Performance Indicator to Analyze Swarm Learning Performances with EHR

Matteo Mantovani, Riccardo Scheda, Carlo Combi, Stefano Diciotti
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High-Risk HPV CISH Detection in Cervical Biopsies with Weak and/or Focal p16 Immunohistochemical Positivity

Daniela Cabibi, Antonino Giulio Giannone, Alberto Quattrocchi, Roberta Lo Coco, Eleonora Formisano, Rossana Porcasi, Viviana Benfante, Albert Comelli, Giuseppina Capra
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A pathogenic variant in the FLCN gene presenting with pure dementia: is autophagy at the intersection between neurodegeneration and cancer?

Irene Bottillo, Luigi Laino, Alessia Azzarà, Carla Lintas, Ilaria Cassano, Vincenzo Di Lazzaro, Francesca Ursini, Francesco Motolese, Simone Bargiacchi, Daniela Formicola, Paola Grammatico, Fiorella Gurrieri
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Nose-to-Brain Drug Delivery and Physico-Chemical Properties of Nanosystems: Analysis and Correlation Studies of Data from Scientific Literature

Bonaccorso A, Ortis A, Musumeci T, Carbone C, Hussain M, Di Salvatore V, Battiato S, Pappalardo F, Pignatello R.
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Oleuropein, a Component of Extra Virgin Olive Oil, Improves Liver Steatosis and Lobular Inflammation by Lipopolysaccharides–TLR4 Axis Downregulation

Leonardo Schirone, Diletta Overi, Guido Carpino, Roberto Carnevale, Elena De Falco, Cristina Nocella, Alessandra D’Amico, Simona Bartimoccia, Vittoria Cammisotto, Valentina Castellani, Giacomo Frati, Sebastiano Sciarretta, Eugenio Gaudio, Pasquale Pignatelli, Domenico...
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Cancer | Complementary methods for the study of interactions between eosinophils and cancer cells

Caterina Antonucci, Adriana Rosa Gambardella, Valentina Tirelli, Fabrizio Mattei, Giovanna Schiavoni
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Hepatic diseases | Non-Invasive Diagnostic Tests for Portal Hypertension in Patients with HBV- and HCV-Related Cirrhosis: A Comprehensive Review

Ciro Celsa, Marzia Veneziano, Francesca Maria Di Giorgio, Simona Cannova, Antonino Lombardo, Emanuele Errigo, Giuseppe Landro, Fabio Simone, Emanuele Sinagra, Vincenza Calvaruso
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Organic Mixed Ionic Electronic Conductor Nanochannels for Vertical Electrochemical and Ionic Transistors

Chenhong Zhang, Lorenzo Margotti, Francesco Decataldo, Alberto Piccioni, Hongzhi Wang, Beatrice Fraboni, Yaogang Li, Tobias Cramer
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Molecular and clinical presentation of UBA1-mutated myelodysplastic syndromes

Maria Sirenko, Elsa Bernard, Maria Creignou, Dylan Domenico, Andrea Farina, Juan E. Arango Ossa, Olivier Kosmider, Robert Hasserjian, Martin Jädersten, Ulrich Germing, Guillermo Sanz, Arjan A. van de Loosdrecht, Carmelo...
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Supramolecular red-light-photosensitized nitric oxide release with fluorescence self-reporting within biocompatible nanocarriers

Francesca Laneri, Cristina Parisi, Mimimorena Seggio, Aurore Fraix, Giuseppe Longobardi, Ovidio Catanzano, Fabiana Quaglia, Salvatore Sortino
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Autonomous Nervous System | Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder

Nicla Mandas; Maximiliano Mollura; Giulia Baldazzi; Parisa Sattar; Maria Mura; Elisa Casaglia …
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ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer

Aldo Ugolotti, Mirko Dolce and Cristiana Di Valentin
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A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy

Chiara Bongiovanni, Hanna Bueno-Levy, Denise Posadas Pena, Irene Del Bono, Simone Redaelli, Max Bergen, Silvia Da Pra, Francesca Sacchi, Carmen Miano, Stefano Boriati, Francesca Pontis, Donatella Romaniello, Martina Mazzeschi, Ilaria...
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Accuracy of intermittently scanned continuous glucose monitoring during caesarean delivery in pregnant women with insulin-treated diabetes

Fabrizia Citro, Cristina Bianchi, Michele Aragona, Tommaso Belcari, Lorella Battini, Piero Marchetti, Alessandra Bertolotto
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Multiplexed imaging to reveal tissue dendritic cell spatial localisation and function

Giuseppe Rocca, Marco Galli, Anna Celant, Giulia Stucchi, Laura Marongiu, Stefano Cozzi, Metello Innocenti, Francesca Granucci
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Lung Disease Management by Iloprost-Loaded Nanoparticles to Address Hyperinflammation Associated with Cystic Fibrosis

Emanuela F.Craparo, Marta Cabibbo, Cinzia Scialabba, Onofrio Laselva, Valeria Daniello, Sante Di Gioia, Massimo Conese, Gennara Cavallaro
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Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity

Martin Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna, Francesco Fiorentino, Dina Robaa, Michael Weyand, Maximilian Puhlmann, Stefano Tomassi, Federica Barreca, Marco Tafani, Elma Zaganjor, Marcia C. Haigis, Wolfgang Sippl, Dante...
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