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Precision Medicine

The right care for you: when medicine meets your biological uniqueness.

Precision Medicine represents a paradigm shift in clinical practice and biomedical research. It moves beyond the "one-size-fits-all" approach to promote innovative models of prevention, diagnosis and treatment built on the individual characteristics of each person.

Unlike traditional medicine, which applies standardised protocols based on statistical averages, Precision Medicine tailors clinical interventions to the biological, genetic, environmental and behavioural characteristics of the individual patient. Therapeutic decisions are refined by integrating data from genomic analyses, lifestyle information, physiological parameters and personal clinical history.

The guiding principle is simple yet revolutionary: “to each their own treatment”. This means more accurate diagnoses, more effective therapies, reduced side effects and a better quality of life. No longer drugs that work “for the majority”, but targeted treatments that work specifically for you.

Precision Medicine is not only a promise for the future, but an operational reality: today we can know in advance which patients will respond to a specific drug, avoiding ineffective treatments and accelerating the path to recovery.

Prof.ssa Sabrina Giglio

Prof.ssa Sabrina Giglio

Responsabile del Centro di Medicina di Precisione HEAL ITALIA, Cagliari<br>Co-Founder Officine
Dottoressa Giglio

The Precision Medicine Centers are concrete access points to the integrated HEAL Italia system. Through the Centers it is possible to:

The Precision Medicine Centers are born to make care truly personal. Every individual has unique biological, genetic and environmental characteristics that influence their health. The Centers use advanced technologies and integrated data to build tailored diagnostic and therapeutic pathways, moving beyond the standardised approach of traditional medicine and ensuring more effective care for all.

The Directors

Dott.ssa Laura Leonardis

Dott.ssa Laura Leonardis

General Director, Co-Founder Officine

Prof. Mauro Piacentini

Prof. Mauro Piacentini

Scientific Director

Prof. Gianluca Moroncini

Prof. Gianluca Moroncini

Full Professor of Internal Medicine, Director of the Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, and Director of the Medical Clinic at AOU delle Marche – Network Coordinator “Prevention Strategies”, HEAL ITALIA Project

Prof.ssa Francesca Granucci

Prof.ssa Francesca Granucci

Full Professor of General Pathology, Director of the Department of Biotechnology and Biosciences, University of Milano-Bicocca – Spoke Coordinator “Next Gen Therapeutics”, HEAL ITALIA Project

Prof.ssa Sabrina Giglio

Prof.ssa Sabrina Giglio

Director of the HEAL ITALIA Center for Precision Medicine, Cagliari Co-Founder, Officine

Prof. Stefano Diciotti

Prof. Stefano Diciotti

Associate Professor of Electronic and Information Bioengineering, University of Bologna – Spoke Coordinator “Intelligent Health”, HEAL ITALIA Project

Prof. Andrea Isidori

Prof. Andrea Isidori

Full Professor of Endocrinology and Metabolic Diseases, Sapienza University of Rome – Spoke Coordinator “4D Precision Diagnostics”, HEAL ITALIA Project

Prof. Piero Marchetti

Prof. Piero Marchetti

Full Professor of Endocrinology, University of Pisa – Spoke Coordinator “Clinical Exploitation”, HEAL ITALIA Project

Prof.ssa Luisa Minghetti

Prof.ssa Luisa Minghetti

Director, Technical-Scientific Service for Research Coordination and Promotion, Istituto Superiore di Sanità – Biobanks Network Coordinator, HEAL ITALIA Project

Prof. Giorgio Stassi

Prof. Giorgio Stassi

Full Professor of General Pathology, University of Palermo – Scientific Coordinator of the HEAL ITALIA Project

Prof. Andrea Perra

Prof. Andrea Perra

Full Professor of General Pathology, UniCA – Director of the HEAL ITALIA Center for Precision Medicine, Cagliari Co-Founder, Officine

Prof. Massimo Midiri

Prof. Massimo Midiri

President of the Heal Italia Foundation, Rector of the University of Palermo

A growing network.
Discover the Centers across Italy

Focus

Officine for Precision Medicine presents Marche BioBank

Officine for Precision Medicine presents Marche BioBank

The event, included in the HEAL ITALIA Roadshow, represents an opportunity for the political, healthcare, academic and business worlds to meet, as it opens new scenarios and prospects for regional...
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HEAL Italia presents Officine for Precision Medicine: the national event on 4 December in Rome

HEAL Italia presents Officine for Precision Medicine: the national event on 4 December in Rome

On 4 December 2025, the Centro Studi Americani in Rome will host the presentation day of the Pilot Programme for the network of Digital Precision Medicine Centers, an initiative that...
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Multi-Omics Approach and Artificial Intelligence in Fibrotic Rare Diseases: A Collaborative Network for Precision Medicine

Multi-Omics Approach and Artificial Intelligence in Fibrotic Rare Diseases: A Collaborative Network for Precision Medicine

The final session of the event "HEAL ITALIA – Precision Medicine: New Prevention Strategies", held on Saturday 27 September 2025 in Ancona, was dedicated to the presentation of Task 4.3,...
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Maternal Exposome and Gene-Environment Interaction in the First 1000 Days of Life: Towards a Maternal-Infant Precision Medicine

Maternal Exposome and Gene-Environment Interaction in the First 1000 Days of Life: Towards a Maternal-Infant Precision Medicine

During the event "HEAL ITALIA – Precision Medicine: New Prevention Strategies", held on Saturday 27 September 2025 in Ancona, Dr. Giuliana Favara presented, also on behalf of Prof. Antonella Agodi,...
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Updating Cardiovascular Risk Functions for the Italian Population: The Cuore Project

Updating Cardiovascular Risk Functions for the Italian Population: The Cuore Project

During the event "HEAL ITALIA – Precision Medicine: New Prevention Strategies", held on Saturday, September 27, 2025 in Ancona, Dr. Luigi Palmieri of the Istituto Superiore di Sanità presented the...
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DIASMOKE: An Innovative Study on Cardiovascular Risk in Diabetic Smokers

DIASMOKE: An Innovative Study on Cardiovascular Risk in Diabetic Smokers

During the event "HEAL ITALIA – Precision Medicine: New Prevention Strategies", held on Saturday, September 27, 2025 in Ancona, Prof. Riccardo Polosa presented via remote connection from Catania the interim...
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Scientific Publications

BEAT – An Agile Design Framework for Telemedicine in Hypertension

Matteo Mantovani, Denise Cosolo, Francesco Pio Anzillotti, Cristiano Fava, Pietro Minuz, Carlo Combi
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Radiomics and deep learning models for CT pre-operative lymph node staging in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Roberto Castellana, Salvatore Claudio Fanni, Claudia Roncella, Chiara Romei, Massimiliano Natrella, Emanuele Neri
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A fluorescent probe with an ultra-rapid response to nitric oxide

Cristina Parisi, Arianna Pastore, Mariano Stornaiuolo and Salvatore Sortino
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ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation

Caterina Licini, Gianluca Morroni, Guendalina Lucarini, Veronica Angela Maria Vitto, Fiorenza Orlando, Sonia Missiroli, Gloria D’Achille, Mariasole Perrone, Tatiana Spadoni, Laura Graciotti, Giorgia Bigossi, Mauro Provinciali, Annamaria Offidani, Monica Mattioli-Belmonte,...
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Cardiac magnetic resonance reveals biventricular impairment in Cushing’s syndrome: a multicentre case-control study

Tiziana Feola, Alessia Cozzolino, Dario De Alcubierre, Riccardo Pofi, Nicola Galea, Carlo Catalano, Chiara Simeoli, Nicola Di Paola, Federica Campolo, Rosario Pivonello, Andrea M. Isidori & Elisa Giannetta
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Control-FREEC viewer: a tool for the visualization and exploration of copy number variation data

Valentina Crippa, Emanuela Fina, Daniele Ramazzotti & Rocco Piazza
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Heal Italia

HEAL Italia is a national foundation that brings together universities, hospitals, public and private institutions to build a new kind of healthcare: human, competent, integrated.

Visit the HEAL Italia website

For any questions about your health

Whether you are facing an illness or looking for answers on prevention, here you will find doctors and researchers ready to listen to you.

Join the Precision Medicine network

Are you a doctor, researcher or institution interested in collaborating? Discover how to join the Precision Medicine Centers and contribute to innovation.